The most solutions obtained from the simulation of heat transfer and fluid flow are in dimensionless form, so that we want to know how to do that in fluent.
Yes, I see many books talks about dimensionless form. In my case I change from dimensionles to dimension then I run in the fluent. After I get the Computational result, I change it back to dimensionless for validation. It is common things. I see several fluent tutorial do the same things.
You cannot solve non-dimensionalized equations directly in ANSYS Fluent. On how to plot graphs/charts in non-dimensional variables in CFD-Post please see the other recent question here in this forum.
ANSYS-fluent works based on dimensional parameters. However, you yourself can reproduce dimensionless forms and then play with thermophysical properties or boundary conditions. For example if you normalize velocity by inlet velocity, then you have to set inlet velocity to unity always or for example you have to adjust the viscosity and density to compensate the presence of Re number in the dimensionless form of momentum equations. However, it is necessary to know exactly what equations are solving by Fluent. Although, it may be simple for laminar flow, I guess it is difficult for turbulent flow. So, I do not recommend this way for turbulent flow.
In general, it should not be the problem to work with nondimensional measures even in Fluent. Just take care of proper conversion of geometry dimensions, fluid flow quantities, material properties, boundary conditions, as well as quantity of time ... if dealing with investigation of unsteady flow.
Formulas for the conversion to nondimensional domain is well enough available in CFD documentation.
Using any calculated field variable, you can write a customized field function (in fluent) of your choice and convert any field variable into dimensionless form.
Also, you can use "export" of your results to Excel ; to convert any field variable into dimensionless form . Actually I used that and it is very easy.