Hello, what I know is that a prolonged exposition of the cells especially the infected ones to trypsin can be be harmful for those especially membrane wise (the membrane is fragilized and there's high risk of deterioration). And who says membrane says cellular receptors too...Anyway if you are doing this kind of experiment right now just avoid a prolonged trypsinization or try to make an optimization experiment just related to your cells characteristics (type of cells, number..), your viral infection and the quantity or time related to the trypsin added.  

Ok, thank you. 

A large number of proteins are reported to act as entry receptors for dengue.  It has been argued that to efficiently spread, dengue has to be able to infect both mammalian and insect hosts, and also infect a variety of different cell types within those hosts.  The non-specific nature of dengue infection makes me skeptical that trypsin would be able to block virus entry completely.  Still, if you try, think about how you will sort out any drop in infectivity (due of receptor loss) from a drop infectivity (due of trypsin toxicity).  You might have to tag your virus so that you can compare cell viability against virus entry. Good luck.