Intraperitoneal chemotherapy has beneficial effects in gastric cancer and is widely used but a form of readily available and cheap chemotherapy to reduce peritoneal mets is on demand .
We used a combination of Mitomycin C and Cisplatin in gastric cancer during HIPEC. But we did not see a long-term beneficial effect. One pt. is alive 1 year after the procedure with progressive disease (liver mets) without any problems from peritoneal metastases. Another pt. died 1,5 years after peritonectomy and HIPEC with symptomatic peritoneal recurrence Our dosing regime was: 100 mg/m² Cisplatin and Mitomycin C 16 mg/m². Perfusion time was 90 min with an average of 41°C.
Hi Dr. Becker, how patients tolerated the removal of the vast majority of their peritoneum? Was any kind of formation of adhesions experienced?
They tolerate this quite well! But after this procedure you can find more or less adhesions. As in othor major abdominal surgery, the extent/amount of adhesions is time dependent. (The longer the time interval between surgery and re-operation, the less adhesions you will find). But there is a large interindividuel variation from severe to not worth mentioning.
I think based on experience ,I have found less adhesions in patients having longer interval between re-operations in majority but as rightly pointed out by Mr.Becker,variations do occur depending on overall response to healing which in turn depends upon so many other factors as well.
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