I spent a long time to look for arginase-1 specific inhibitor, but could not find. Is there anyone who knows this kind of drugs? It seems most drugs target both arginise-1 and -2.
FROM Wikipedia:
2(S)-amino-6-boronohexonic acid (ABH) is an L-arginine analogue that also creates a tetrahedral intermediate similar to that formed in the catalysis of the natural substrate, and is a potent inhibitor of human arginase I.
Cox JD, Kim NN, Traish AM, Christianson DW (November 1999). "Arginase-boronic acid complex highlights a physiological role in erectile function". Nature Structural Biology 6 (11): 1043–7. doi:10.1038/14929. PMID 10542097.
The inhibitor NOrNOHA is somewhat specific.
Archives of biochemistry and biophysics
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Inhibition of Human Arginase I by Substrate and Product Analogues
Luigi Di Costanzo, Monica Ilies, [...], and David W. Christianson
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