The specific area of fate regeneration I am referring to is the nasolabial folds. Imagine that you have a patient with a bodyfat percentage of 3% and not the typical nasolabial fold patient who has them due to being overweight. The area is very thin and has almost no fat in or around it. The "fold" to be treated is a fine line that is not in the skin but the fat, and the patient is young(as in 21-24). Could injecting prp in the creased area induct fat regeneration? I am talking about permanant results, as in repair or regenerating the fat, not temporarily hiding the lines while your time dwendles until the next injection date. I do not want to plump up the area or use prp as a filler. Do not suggest using fillers as they are an absolute disgrace to science and medicine.
Not the answer you are looking for but 3% body fat is clearly unhealthy to begin with - how about better and balanced nutritional regimen rather than looking for a "long-term" local "fix" while not dealing with the underlying problem! ;)
There are several papers/reviews that suggest PRP can improve fat grafting/retention via induction of angiogenesis. Here is a brief review below:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631549/
I'm afraid that I disagree with AND do not understand (not referring to your various errors in spelling and grammar) a number of your points. My comments are as follows:
1) Nasolabial folds are not due to being overweight, rather, midface structural volume-loss (along with loss of skin-elasticity and some effects of gravity) causes the folds to increase in 'severity';
2) What do you mean by a 'fine line' in the fat?;
3) PRP does not 'regenerate' fat, but 'supercharges' lipografts to increase survival of the transferred fat (e.g. due to angiogenesis, and by enhancing the natural antibacterial properties);
4) PRP as a filler is a flawed concept (and clinicians should not be 'solely' using PRP for such a purpose). At the very least, in the face, with such high blood-perfusion, the 'goodies' in PRP are washed away;
5) Why have you referred to fillers as a disgrace?! Firstly, fat is a filler (autologous), so I cannot see what is disgraceful about that. Secondly, if your statement is supposed to refer to ‘non'-autologous fillers, such as hyaluronic acid fillers (e.g. Juvéderm and Restylane), then they have been shown to be incredibly safe with great outcome-satisfaction. Furthermore, histological analyses have demonstrated their integration into the skin over long-term-use, and should their placement be suboptimal, they can be dissolved with enzyme.
I agree with Tausif Alam's thoughts as a good discussion point to have with the patient in question, to start off with. Also, tell us more about this patient, e.g. weight, body mass, occupation (body-builder?), systemic diseases, et.c..
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