there are many mouse models that inoculate human cells, such as tumor cells or T cells, to the mice, whether could it induce the phagocytosis of the mouse macrophages to human cells? even in the immune incompetent mice...........
Hi,
However, as macrophages have the ability to present antigens to T cells and function as effectors for cell-mediated immunity, it is known that they affect the development of infectious diseases, cancers, and chronic inflammatory diseases such as arteriosclerosis.
This link will help you find the answer. https://www.researchgate.net/post/Can_I_perform_my_Phagocytosis_Assay_with_murine_macrophages_and_human_cells_as_prey_cells
If your question is whether this happens during in vivo models...it's hard to say. I would say not likely because the cell size is quite a lot bigger than what is normally phagocytosed. AND what on a T cell woulld promote phagocytosis? The cell surface of a cell is much more diverse than a bacteria/virus, etc (most surface proteins to promote phagocytosis hit things like PRRs). How would a T cell get oposonized?
The only way it might happen is if the T cells starts to die (whatever mechanism). Then the death markers does actually promote phagocytosis.
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