Interaction between leishmania and dendritic cells are central in understanding of DC activation post infection. There are reports that Leishmania in known to suppress DC activation and suppression of expression of co-stimulatory molecules like CD4O and CD86. I am not sure about CD80, but since it is also a co-stimulatory molecule needed to activate T cells is is highly probable that there should be suppression in the level of these molecules also. However when DCs were primed with LPS a known agonist of TLR4 followed by infection with L. major there was a quantitative suppression in gene expression of these molecules. When heat killed parasites were used to prime DCs the effect of LPS was sustained.
This demonstrate that promastigotes are known to suppress the expression of cell surface co-stimulatory molecules, once the DCs are previously primed with TLR ligands.
THANK YOU for these clarifications
Can I ask you to cite me the article which noted a quantitative suppression in gene expression of these molecules in DCs primed with LPS and followed by L. major infection?
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