Hello Everyone,
I'm working on a heterozygous gene. It have dominant mutant and recessive wide type. So I just had question that can both of these copies can be expressed into pre-mRNA?
Thanks,
Sachin
It really depends; in some cases the recessive gene is transcribed at a slower rate and in other cases it is not transcribed at all.
Dear Sachin
In your question , you said dominant allele, there are degrees of dominance: completely dominant ( the dominant allele prevent the recessive from expression), Incomplete dominant ( the heterozygous phenotype can be distinguished from homozygous phenotype, due to the effect of the dosage of the gene AA has double dosage compared with Aa ), No-dominant and some times call Codominant ( the both alleles express in phenotype independently ).
So, you may ask about the No-dominant case.
Good Luck
The short answer is YES. A study investigated and predicted mono and bi-allelic expression of all human genes in late nineties in PNAS.
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