Food as a culprit in devolvement of neurologic diseases is not a novel concept, as there is a history of specific neurologic diseases that are caused by deficiencies in nutrition, namely lack of certain foods in human diet, like vitamins. There are also diseases caused by excess of some nutrients, and even vitamins. This review, however, is not about these well-known conditions. It is about potential indirect effect of what is considered a “healthy” balanced diet in development of neurologic diseases. We discuss what is known about gluten sensitivity and neurologic disorders, and we extrapolate that there might be a much wider array of intolerances-sensibilities which don’t have yet an objective marker. We also expanded on a hypothesis that maybe other neurologic disorder with immune mechanism like MS might be a target of immunological overload of other antigens apart from gluten.
Such studies are important for mankind and increase health information.
Good luck
Thanks dear Alaa Abed for the support and optimism contained in your comment.
hi
in addition to the food itself you should have a look on the way it have been produced and see if pesticides have been used and could be associated with the neuro diease.
fred
Dear Milorad
Pls. find the attached files,
Hoping this will be helpful to your project, good luck
Regards
Prof. Houda Kawas
https://www.hopkinssjogrens.org/disease-information/sjogrens-syndrome/neurologic-complications/
https://www.foodintol.com/latest-news/16-medical-research-news/5-inflammatory-disease-and-food-intolerance
http://emedicine.medscape.com/article/1146199-overview
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034518/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967529/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069023/
https://www.nytimes.com/2014/10/12/opinion/sunday/can-celiac-disease-affect-the-brain.html
http://journals.sagepub.com/doi/full/10.1177/1759091414568185
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/neurology/multiple_sclerosis/
https://www.hindawi.com/journals/ad/2012/969657/
Also
http://www.lifeextension.com/protocols/neurological/multiple-sclerosis/page-01
https://www.scientificamerican.com/article/important-link-between-the-brain-and-immune-system-found/
https://myelitis.org/living-with-myelitis/disease-information/
http://www.nature.com/mp/journal/v21/n6/full/mp201650a.html
http://www.direct-ms.org/pdf/NutritionMS/B12%20and%20MS.pdf
Most of these diseases are related to signals and pathways, and any change or modification of these signals by different substances will change these vital complexes
Regards
Dear colleagues Frederic Lepretra and Houda Kawas, thanks for the more constructive discussion and positive comments.
Many disorders have a different prevalence in males and females indicating a role of sex hormons. Moreover, the male to female ratio of MS, Alzheimer and Parkinson Disease has changed across the years suggesting that environmental factors (e.g. endocrine disruptor compounds, EDCs) may be involved. Some EDCs are pollutant which may contaminate our food, but there are also natural molecules as phytoestrogens (very high in soy food) which are able to interfere with neuroendocrine system and may increase/decrease the risk of specific diseases.
Here are few references:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245362/
https://www.ncbi.nlm.nih.gov/pubmed/24486046
https://www.ncbi.nlm.nih.gov/pubmed/18693302
https://www.ncbi.nlm.nih.gov/pubmed/26890773
https://www.ncbi.nlm.nih.gov/pubmed/26497928
Thanks to everyone you've joined in the discussion with one more addition:
What is relatively new is that vitamin D in blood can be considered as a biomarker for MS and its sudden drop as an indicator for intensification of supplemental Vitamin D therapy in order to reduce risk of relapses and degree of disability. Furthermore, epigenetics is suspected to have a significant role in the pathogenesis of variety of autoimmune disorders including neurological manifestations. Also, some new research suggests that cow's milk might be involved in development of MS based on epigenetic up-regulation of immune pathways. This leads us to a hypothesis that what is considered a “healthy” balanced diet might be indirectly involved in development of neurologic diseases. For example, whole grain flour products were considered healthy prior to discovery of connection between gluten sensitivity and celiac disease, including neurologic disorders, with a gliadin antibody as a marker. Therefore, what is healthy for most people, can be detrimental for gluten-sensitive individuals. Our hypothesis extrapolates from "healthy diet-gluten sensitivity" issue that there might be a much wider array of intolerances-sensibilities which don’t have yet an objective marker. This is further supported with growing evidence that gut microbial communities can modulate the host’s innate and adaptive immune system. In the light of the known fact that dietary changes affect both the composition and function of the gut microbial communities, we suggest the possible mechanism of autoimmune disorders as a result of interaction between individual's diet and his/hers genetic make-up, and epigenetic influence.
appart from food itself, man must take into account pesticides and so on used in agriculture and these have been proved to be involved.
fred
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