The International Myeloma Working Group proposed a risk classification for multiple myeloma based on FISH. For high risk is necessary at least one of the following: del17p, t(4;14), or t(14;16).
As FISH is expensive, I am thinking in other alternatives to study this 3 cytogenetic abnormalities (CA).
Arun Kumar Arunachalam
Yes. However you would have to do both the procedures- MLPA for del17p and RTPCR(cost effective than RQPCR) for the two translocations. MLPA has the advantage of covering many other deletions although their exact prognostic role is not well defined yet. To do both MLPA and RTPCR u need both DNA and RNA and I am not sure whether it will be cost and labour effective than FISH which is what u intend to achieve.
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