Can blood serve as a surrogate for brain gene expression pattern?

More Muneeb Faiq's questions See All

Is "thinking" an act of science?

When we think, what do we do? Do we philosophize or exercise science? Neither, either or both? How is thinking not science and how is thinking an act of science? How is it philosophy and how not a...

06 July 2019 1,519 5 View

What is theoretical Medicine?

Why cant there be a journal dedicated to the field of medicine which does not yet have any experimental basis much like theoretical medicine?

06 July 2019 1,553 9 View

Where can we submit/publish general philosophy essays?

There are limited places/portals/magazines that publish unsolicited general philosophy essays. Could anyone guide me how can I get my essays published on regular basis? Thank you

06 July 2019 6,550 2 View

How is artificial intelligence same or different from your intelligence?

How is artificial intelligence same or different from what we conventionally call natural intelligence?

06 July 2019 3,558 6 View

What does it mean to exist?

What does it actually mean to exist? How is it different from non-existence? How can we be sure if something exists or does not exist? I have made a case that these questions are more fundamental...

04 May 2019 5,416 24 View

Does "Sense of Humor" play any role in health and disease?

07 August 2018 4,736 5 View

Is slight illness is a good thing?

Are there any uses of illness or it is just all evil?

07 August 2018 3,386 1 View

How to publish a hypothesis without experimental data?

05 June 2018 5,443 8 View

Difference between Dye and Stain?

What is the difference between Dye and Stain in Biological Experiments?

05 June 2018 1,260 2 View

Stress can cause vision loss?

http://www.timesnownews.com/health/article/psychological-stress-could-cause-blindness/243759

05 June 2018 5,065 6 View

Why did the authors extrapolate a phenotype that they experimentally proved in one bacterial strain across the whole genus of the organism?

I aim to be as skeptical as possible regarding whether a pair of orthologous genes results in the same phenotype in their different but related bacterial organisms under similar environmental...

05 August 2024 6,787 4 View

Why my colony PCR results of my recombinant bacterial not showing any results?

I am performing ligation of the plasmid and a target gene. The steps I have taken are: 1. Double digestion of the plasmid and target gene 2. Ligation of the plasmid with the target gene 3....

05 August 2024 2,570 3 View

The Curse of Evolution and Complexity?

Brain and body mass together are positively correlated with lifespan (Hofman 1993). The duration of neural development is one of the best predictors of brain size, and conception is the best...

05 August 2024 6,247 3 View

ANY free software for reconstructing neurons in the microscopic image?

Hi everyone, I am working on brain slices for visualizing a protein in the soma and dendrites, using a fluorescence tag. However, I need a tool (not paid) for reconstruction of the whole neuron,...

04 August 2024 4,725 2 View

In what part of the brain´s rabbit bdnf is located and include references please?

I´ve been unable to find specific information about this neurotrophin in the CNS of rabbits exclusively. There is extensive info in mice, fish and rats, but in brain´s rabbit is hard to find....

04 August 2024 762 1 View

Do You Know Untreated TMJ Affects Your Brain And Entire Body?

04 August 2024 6,282 1 View

What is the best protocol for freezing the rat brain in preparation for protein detection by Elisa ?

What is the best way to freeze the rat brain - liquid nitrogen, Dry ice , isopentane - after isolation for later protein investigation by Elisa?

01 August 2024 1,722 1 View

How to Post-fix Mice pup's brains?

I need to Postfix mice brains. I slice the brains using microtome at 40 microns. These are Postnatal days 7, 11, 14, and 21. I am using half the brain for other analysis, so I need to fresh freeze...

31 July 2024 1,123 4 View

What is the acceptable p-value cutoff for GO enrichment analysis ?

I have an RNA-seq data that I have analysed using Limma-voom and have extracted the gene IDs, log2FC and the p-values. At p value < 0.05, I have over 10,000 DEGs, however, when I run the GO...

31 July 2024 225 2 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Craig Silver

No. There is a tissue specificity to many genes. For instance, genes that are well expressed in blood (hemoglobin?) would have a far reduced expression in brain tissue

Hassan Nima

this link is useful

Article Huntington’s disease blood and brain show a common gene expr...

regards

Beemnet Mengesha Kassahun

Interesting Question and Following for knowing more about the issue.