Bariatric surgery is a potential treatment option for overweight patients with type 2 diabetes, hypertension, and dyslipidemia.
For what is know the number of cells is kind of stable, but their size decrease dramatically, so you may have similar number, but smaller adipocytes.
Thank you Pedro. Yes indeed. However, why patients who underwent this type of surgery reduce their appetites?
Hi. I guess you potentially will affect expression of GI and adipose derived signalling peptides (ghrelin, Glp1, leptin, cck, pyy etc.) and the fine balance between these that indeed will affect appetite. Remember also that nutrients will affect hypothalamic signalling peptides (via circulation and Vagus innervation) to control appetite.
Hi Bjursell
Thank you for this clarification which supports my hunch
Bariatric surgery has the effect to reduce the size and the number of fatty cells and besides highly important reduces the number and quantity of proinflamatory cytokines. Close together in the program that includes bariatric surgery and good postoperative counceling for eating strategy and fisical activity leads to optimal reducing of risk factors.
The key to the bariatric surgery is the fine line between cosmetic and medicine,although it is gaining popularity in the modern obese world,a detailed pre and post operative counseling is very essential to reduce morbidity and at times mortality.
Both omental and subcutaneous adipocytes shrink dramatically with bariatric surgically induced weight loss. Data about this will be found in: P.D.Berk, F. Ge, H. Lobdell IV, J. L. Walewski, G.Dakin, A.Pomp, W.B. Inabnet, M.Bessler. Adipocyte Size and Facilitated Fatty Acid Uptake are Independently Regulated in Obesity and During Bariatric Surgical Weight Loss [Abstract]. A poster presentation (T-383-P) at the Annual Meeting, The Obesity Society, Atlanta, GA, October 2013. Obesity 2013: Abstract Supplement, pg S142. Determining changes in adipocye cell number in humans is technically more difficult. In rats, changes in the weight of epididymal fat pads with changes in body weight reflect almost entirely changes in adipocyte cell size in some strains, but changes in both cell size and cell numbers in other strains.
Paul D. Berk, MD. Columbia University Medical Center
Before the complete human growth it is possible reduce di adipocyte cells number. After it is possible only reduce the size.
Bariatric surgery decrease the size of the fat cells but not the number.Fat cells are matured by the time we offer Bariatric surgery.
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