Currently, I am working on the PLA-PEG polymer micelle for the drug delivery system. The micelle I have synthesized I got avg 900nm particle size on DLS. I want to reduce the particle size below 200nm.
Dear Anwarul Azim Akib, the simplest way is by reducing copolymer block length, mainly PEG one. My Regards
Dear Anwarul Azim Akib, the simplest way is by reducing copolymer block length, mainly PEG one. My Regards
It's hard to believe that PLA-PEG micelles have such particle size; they should be much smaller. I presume that you have some aggregates in solution that coexist with real micelles. DLS is very sensitive to large objects. Try removing these aggregates by filtration as John Francis Miller suggested above. I bet you should be able to measure micellar size after filtration.
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