Hi Fernan,

The Axoclamp 900A is great. This being said, you mention working on muscle cells (skeletal I believe?) - have you look at the "silicon-clamp" approached developed by Vincent Jacquemond? It is a great and cleaver approach to voltage-clamp properly big cells using a conventional patch clamp rig and single electrode. https://www.ncbi.nlm.nih.gov/pubmed/25023307

Hope it helps - good luck!

Thanks Norbert! I need to take a look at silicon clamp. At the outset I think that the ease of the method might be compromised by the difficulties of enzymatic isolation

Thank you very much for the 900A recommendation.

Best regards.

I didn't do any patch clamp work in the past, sorry about that..

Chen-Yu

Thank you Jonas! This is very helpful. I am especially interested in their clamp  for larger (e.g muscle) cells. They sound really solid.