I was wondering if anyone here has any experience with using spike-ins for DNA sequencing? I was thinking of using a spike-in with some ChIP-seq data. I know spike-in has been used for RNA-seq and there is a ERCC kit available from Ambion (aka NIST spike-ins), however, this is RNA and I would need to convert it to dsDNA. I was thinking of ordering synthesized oligos based on the ERCC sequences and I was wondering if anyone has done something similar before.