Is it important to determine in vitro-in vivo correlation, when talking about PLGA nanoparticles release? Why it is important? Are there special criteria for nanoparticles suitablity in case of in vitro-in vivo correlation?
I ask those questions because there are so much papers with PLGA nanoparticles characterization, but none of them has a detailed explanation of the release kinetics results.
Hi,
Not necessarily for nanoparticles, but you may find the following literature useful (keeping in mind the question of: are there any acceptable correlation between animal studies and clinical studies data?):
[Full text] Preparation and in vitro/in vivo evaluation of PLGA ...
https://www.dovepress.com/preparation-and-in-vitroin-vivo-evaluation-of-plga-micro...
Apr 5, 2018 - Preparation and in vitro/in vivo evaluation of PLGA microspheres ... In vitro dissolution test shows the prepared microspheres release for over the 20 days. ... Therefore, good in vitro–in vivo correlation was established. ..... loaded into poly(lactic-co-glycolic acid) nanoparticles against Schistosoma mansoni. -------------------------------------------------
In vitro and in vivo characterization of temoporfin-loaded PEGylated ...
https://www.futuremedicine.com/doi/10.2217/nnm.11.130In vitro and in vivo characterization of temoporfin-loaded PEGylated PLGA ... glycol (PEG) Poly-(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) as a new ... and the release of temoporfin monomers was faster from PEGylated PLGA .... PLGA nanoparticles: correlation between nanoparticleproperties and in vivo activity.
__________ ____________ ___________
In Vitro–In Vivo Correlations of Scalable PLGA-Risperidone Implants for the Treatment of Schizophrenia
- August 2010
- Pharmaceutical Research 27(8):1730-7
Dear M. R. Mozafari ,
Thank you for the answer. Papers you attached are really interesting.
But why do you suppose that correlation is not necessarily for nanoparticles? Could you give more information on this.
Dear Maria,
Sorry for making you confused. By saying:
"Not necessarily for nanoparticles, but you may find the following literature useful ..."
I meant those papers were not necessarily dealing with nanostructures / nanoparticles.
I am glad you found them useful for your research.
Is Prof. Renat Zhdanov still associated with your institute? He was my supervisor and is an eminent and very talented scientist.
Thank you for clarifying.
Maybe you ment Moscow State University? Unfortunately, I am not acquainted with Prof. Zhdanov.
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