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Questions related from Maria Sokol
I need to replace entrance lens in my flow cell. Looking for used lens or replacment kit to buy it.
19 October 2018 5,382 1 View
I am working towards biodistribution study the first time now. And it is unclear for me how much tissue sample (lungs, liver, kidneys, heart, spleen, testicles) should I treat to homogenize and...
23 August 2018 797 2 View
Is it important to determine in vitro-in vivo correlation, when talking about PLGA nanoparticles release? Why it is important? Are there special criteria for nanoparticles suitablity in case of in...
29 July 2018 6,565 4 View
I need to carry out pharmacokinetics study on rats by HPLC. Should I take drug from tissue samples for this purpose or only blood samples investigation will be enough?
15 June 2018 7,046 9 View
I need to conjugate PLGA with carboxylic end and peptide (1061 Da). The peptide has two unprotected NH2-groups. When using EDC and NHS (PLGA:EDC:NHS = 1:5:5, molar ratio) the percentage of...
06 February 2018 2,608 3 View
What system is it prefereble to use for determination of docetaxel LD50? I utilized dissolution system that is used for clinical application, but it is not sutible in my case because of little...
26 June 2017 1,621 5 View
There are several protective groups in my peptide sequence: Fmoc, Boc, Trt, TBS, Dde, Cbz. How can I selectively remove Boc?
22 June 2017 8,271 2 View
I utilize dialisis for release determination with PBS (pH 7,4) + surfactant (1% PVA). After about 2 hours a precipitate was formed in dialisis bag (I believe this was my released drug). So I...
30 April 2017 1,148 7 View
I need to separate two compounds with pKa 5,19 and 10,96. Which buffer should I use and which pH is more suitable?
02 March 2017 6,039 3 View
