concentration for free drug should equal to all drug-loaded nanoparticle OR have equal to drug inside carrier nanoparticle
which one is correct?
for example free drug 100ug/ml , drug loaded also 100ug/ml Or should be increased( example 500ug/ml) until get drug inside is 100 ug/ml?
You should take the help from your colleagues belonging to biochemistry and better biotechnology department. Moreover your query is not clear and specific.
Deer Shamma
If the nanoparticles were drug vehicles, means that they will accelerate and specify the target of the drug, then I think the drug loaded nanoparticles will be needed in less amount than the drug alone. but you should try to determine the exact dose by examining many gradual doses practically and not to depend on theoretical calculations in such situation.
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