I just want to know why igf-1 level is seen in type 2 diabetics over insulin....what the actual advantage
Dear Sarmistha Sarkar
Simply stated it looks like increases in insulin should lead to increase in IGF-1 leading to further downstream stimulation to cause increase growth. We usually find higher IGF-1 in obese people. However the relationship as I reviewed is not so straightforward. This seems like a grey area as the relationship between IGF-1 and insulin does not seem to be straight forwards.
1- Friedrich N et al has shown that both LOW LEVELS and HIGH LEVELS of IGF-1 are associated with insulin resistance as measured by HOMAIR. This is depicted as below:
So we can see a U-shaped association between IGF-1 and insulin. v(Diagram attached)
Reference: Friedrich N et al . The Association Between IGF-I and Insulin Resistance. Diabetes Care. 2012 Apr; 35(4): 768–773. doi: 10.2337/dc11-1833
2. Schneider HJ et al have also demonstrated that both low IGF-1 and HIGH IGF-1 are predictive future diabetes risk.
Reference: Schneider HJ et al. Prediction of incident diabetes mellitus by baseline IGF1 levels. Eur J Endocrinol. 2011 Feb;164(2):223-9. doi: 10.1530/EJE-10-0963.
Keeping in view the structural homology between insulin and IGF-1, some studies have demonstrated a positive relationship between the two parameters. However, the data is not consistent and varies and can be key area for further research.
FINAL WORDS: The advantage seems minimal but obesity in diabetes can lead to higher IGF-1 in few cases and this area need to be research more.
Warm regards
Dr Sikandar
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