Can any one provide reviews on tumor hypoxia and periostin gene function?

More Phani Bhushan Meka's questions See All

Is it safe to open educational institutes amid new cases of Covid-19 without completion of vaccination??

Vaccination is in its First phase in India. The front line is to be vaccinated yet. In this situation opening of institutes may be dangerous for the life of children.

01 February 2021 660 2 View

What is the maximum voltage a piezoelectric PZT layer can handle?

I have a circular PZT layer deposited by PLD method. The dimensions are: 20um diameter and 350nm thick. It has 100nm Pt electrodes sputtered on the top and bottom. I would like to know what is the...

25 January 2021 688 5 View

Which are the best methods to graft the polymeric nano/micro particles with lipids?

Good references (with clearly written methods/protocols) are highly appreciated. Polymers could be any, e.g., PLA, PCL, PLGA, etc. Similarly, lipids could be DSPE, DMPE, DMPA, DPPE, DLPC, DOTAP,...

07 December 2020 5,085 4 View

How to build a polymer pdb file from a monomer pdb file, for using it is an initial configuration in Gromacs?

I am doing my Ph.D. in Materials Science and am completely new to Molecular Dynamics Simulation and Linux. I am using Manjaro Linux 20.1 and have Gromacs 2020.4, VMD 1.9.3, packmol 20.0.10,...

28 October 2020 1,051 3 View

I am looking for an open source seismic hazard and risk analysis software. Is there any software available free of cost?

Open source and easy to learn with proper documentation.

26 April 2020 4,994 2 View

Why are there flow of water from land towards ocean?

Water in land always has a tendency to move towards ocean. I eager to know the reason behind this.

23 January 2020 3,069 5 View

How is dissolved salt in surface water originated in inland areas?

Inland surface contains so many dissolved salts into it. What are the sources of these salts, I like to know.

23 January 2020 7,686 4 View

Which has more evaporation rate surface water or sea water and why?

Surface water resources like ponds, lakes, reservoirs and rivers and sea water undergo solar evaporation in presence of sunlight. I like to know which one has higher evaporation rate.

22 January 2020 4,114 5 View

How can organically bound Nitrogen be determined in soil/sediments?

Most fraction of nitrogen in soil belongs to organic matter present in soil, but soil contains other fractions like nitrate, nitrite and ammonia form together. Then how organic bound nitrogen...

17 January 2020 6,570 6 View

Why are essential elements present in earth crust in abundant than toxic heavy metals?

The composition of earth crust reveals that the biological essential elements are abundant in comparison to the toxic group of heavy metals. What could be the reason behind this?

16 January 2020 2,028 3 View

Anyone plz suggest relevant topic for research in image processing+Deep learning.?

I have selected brain tumor images ...but now found that already lots of research done n this topic.

03 March 2021 5,774 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Is it possible that Cancer cells could survive in heparinized blood for 48 hours?

Hi everyone, I am just wondering if we incubated 200 microliter of whole blood with 50 microliter of cancer cells(1bout 5000cells) do you think that cancer would survive for 48 hours?

23 February 2021 3,840 3 View

The PC12 cell line characteristics?

Hello dear scientists, Does the undifferentiated PC12 cell line in terms of chromosome characteristics, proliferation, and drug reactions have the characteristics of cancer cells? Where is it...

21 February 2021 8,945 3 View

What is the minimum number of exosomes/ml to have a good yield of total RNA for Illumina sequencing?

I am using IZON qEV2 columns to isolate exosomes from 100 ml of cancer cell conditioned medium. in NTA analysis I usually see concentration of 2x10^9 particles/ml. But when I proceed with this...

20 February 2021 6,879 3 View

Can the viability assays (ex: MTT/CCK-8) measure cell proliferation? or are they solely viability assays?

I want to conduct a proliferation assay to test a chemotherapy combination on a cancer cell line. At first, I thought about the MTT assay. But now, all sources are saying that these do not measure...

14 February 2021 3,142 7 View

Which Journals would you advise to submit a Letter which briefly talks about neurosurgical treatment of neuro-oncological patient during Sars-COV-2?

Possibily not an open access journal which does not add any publishing costs once being accepted. Thank you in advance

09 February 2021 717 6 View

Go J Yoshida

Review

The multifaceted role of periostin in tumorigenesis.(Cell Mol Life Sci. 2009 Jul;66(14):2219-30.)

Periostin: novel diagnostic and therapeutic target for cancer.(Histol Histopathol. 2007 Oct;22(10):1167-74.)

Original Article

Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-β signaling (Biochem Biophys Res Commun. 2013 Nov 8;441(1):126-32.): Periostin increases PHD2 mRNA, but decreases HIF-1α protein, in hypoxic cells.

Periostin-binding DNA Aptamer Inhibits Breast Cancer Growth and Metastasis (Molecular Therapy (2013); 21 5, 1004–1013. )

Chithan C Kandaswami

Helpful reviews on tumor hypoxia:

http://www.cancerandmetabolism.com/content/pdf/2049-3002-2-3.pdf

Masson and Ratcliffe

Cancer & Metabolism 2014, 2:3

http://www.cancerandmetabolism.com/content/2/1/3

http://jnci.oxfordjournals.org/content/93/4/266.full.pdf+html

http://pfeifer.phas.ubc.ca/refbase/files/Moulder-CancMetastRev-1987-5-313.pdf

http://www.nature.com/nrc/journal/v4/n6/full/nrc1367.html