Does anyone know the brain concentration or % of antibody that was able to pass the BBB in patients treated with Abeta antibodies bapineuzumab or solanezumab? Thank you.
The papers I saw explained about 1% for general antibodies. With the dysfunction of the BBB, it may go up a few %. But remember that Abeta is in decent levels in the blood and these antibodies will likely bind targets in the blood first...