Upon some research I found different protocols of BPA solubility, some state a 5 v/v % ethanol (MOTOYAMA et al ) will catalyze the process of solubility and BPA will stay in solution (being an azeotrop the ethanol won't evaporate). The European Union Risk Assessment Report CAS: 80-05-7 EINECS No: 201-245-8 states that BPA solubility in water is 300 mg/L so does pubchem. How can I get a solution of more than 300 ppm BPA completely dissolved in water preferably without ethanol? Will dmso work as good? Waiting for your replies. Thank you
Not myself, but one of my previous colleagues tired to solve BPA in DMSO to use in cell culture. The biggest problem was DMSO concentrations were so high in their dose range and when they decrease DMSO concentration there was solution problem. Additionally, she told me that there was phase separation during incubation. I hope it helps.
Thank you @Unzile Sur yes ..BPA is such a capricious compound when about solubility...
Hi,
you said " How can I get a solution of more than 300 ppm BPA completely dissolved in water preferably without ethanol " when 300 ppm is an aqueous solubility, isn't? So, you cannot prepare a stable aqueous solution at the BPA concentration exceeding 300 ppm. Or did I understand you wrongly? Regarding aqueous solubility data, it might be worth to always check what is the source of the value published. It is often calculated, based on empirical correlations, and, in this case, the order of magnitude error is well possible. Finally, BPA is phenol. I guess, in highly basic solutions, perhaps, even at pH 9, its solubility will increase dramatically
Mikhail Borisover Thank you for your answer. Yes, that s correct, my question was"... How can I get a solution of more than 300 ppm BPA completely dissolved in water preferably without ethanol? " I did checked the source, funny that one states 170 at 25C, other 300 at 25C other none, but the one that says 300 at 25 C is true,. so you are stating that a higher pH will increase solubility, makes sense, will give it a try.
I would suggest dissolving it in methanol first and then using it such that the final concentration of methanol is not more than 0.5%
I agree, increasing pH works well when dissolving BPA. We have similar experiences.
0.5 mL of EtOh disolves 500 mg of BPA without any issues, water can then be added Motoyama et al.was right all along, the solution will not ...flocculate ..
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