Given that blood is predominantly utilized in laboratory testing, I'm interested in exploring alternative sample sources for situations where obtaining blood from the patient proves challenging.
In addition to blood, lactate dehydrogenase (LDH) activity can be evaluated in various tissues and body fluids such as cerebrospinal fluid, urine, and ascitic fluid. These alternative sources can provide valuable information in diagnosing and monitoring various conditions and diseases.
Other body fluids can be used for the evaluation of Lactate Dehydrogenase (LDH) activity. For instance, cerebrospinal fluid, peritoneal fluid, and pleural fluid may be utilized to measure LDH activity. According to the University of Rochester Medical Center Rochester, NY (2024), cerebrospinal fluid LDH can assist in the diagnosis of conditions affecting the central nervous system including Creutzfeldt-Jakob disease, bacterial meningitis, and neurosyphilis. While Schneider et al. (1997) stated that peritoneal fluid LDH might be a useful biochemical marker for ovarian cancer detection. Moreover, Gallagher (1984) stated that pleural fluid LDH can be used to differentiate between exudates and transudates. An exudate is suggested by a pleural fluid LDH ratio greater than 0.6, but a transudate typically has a ratio smaller than 0.6.
References:
Gallagher, C. G. (1984). Lactic Acid Pleural Fluid Dehydrogenase. Archives of Internal Medicine, 144(2), 414. https://doi.org/10.1001/archinte.1984.00350140248040
Schneider, D., Halperin, R., Langer, R., Bukovsky, I., & Herman, A. (1997). Peritoneal Fluid Lactate Dehydrogenase in Ovarian Cancer. Gynecologic Oncology, 66(3), 399–404. https://doi.org/10.1006/gyno.1997.4792
University of Rochester Medical Center Rochester, NY. (2024). Lactate Dehydrogenase (CSF) - Health Encyclopedia - University of Rochester Medical Center. Www.urmc.rochester.edu. https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=lactate_dehydrogenase_csf
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