What is the best way of processing very large files in python?

I want to process a very large file, let's say 300 GB, with Python and I'm wondering what is the best way to do it. One limitation is that my algorithm needs the whole file in memory, so a...

15 January 2021 6,691 4 View

Has anyone compared supervised classification methods using google earth engine?

Good Morning! Has anyone compared supervised classification methods using Google Earth Engine? Could you comment on what are the criteria you used to decide on any method?

29 November 2020 544 4 View

How is dislocation density related to bulk defect density?

In materials science, a dislocation (line defect) represents a linear crystallographic defect within the crystal structure, which causes an abrupt change in the arrangement of atoms, which in turn...

27 July 2020 4,064 7 View

What are the activation functions to be used for a regression based Artificial Neural Network?

I am designing a Neural Network with two hidden layers for a regression problem in Python. While all inputs are positive, there are supposed to be negative values in the output. The model was...

09 July 2020 6,308 3 View

How can I find the correlation coefficient between 1 categorical variable compared to several other variables?

Let's say that I have 8 proteins: A-H and I have protein expression data for each gene. For each gene, the expression number is based on the average of 20 cell lines expressing that gene. I also...

10 May 2020 3,261 1 View

How to measure the center of gravity from forceplate data?

Some articles published a long time ago proposed several ways to estimate the center of gravity using the center of pressure collected from the forceplate [Shimba 1982, Benda 1994, and Caron...

11 March 2020 7,982 3 View

Can anyone clarify the difference between IC50 and dose to me?

I guess I'm not understanding the concept well. If I treated cells (5000/well) with a range of doses from 6nM to 92nM (and this is an MTT assay and I've used Prism8), why is the IC50 only .9nM? I...

24 February 2020 7,044 2 View

Is it really necessary the clean-up step after PCR for digesting with DpnI?

I've read different protocols, starting for the QuikChange one, and there's no call for cleaning up after PCR. However, I did clean up as suggested by other researchers, so the polymerase doesn't...

12 November 2019 9,677 5 View

Is it really necessary the clean-up step after PCR for digesting with DpnI?

I've read different protocols, starting for the QuikChange one, and there's no call for cleaning up after PCR. However, I did clean up as suggested by other researchers, so the polymerase doesn't...

10 November 2019 5,183 5 View

What is the effect of junction partner layers (adjacent to the absorber) on photogenerated voltage in a solar cell?

How do absorber partner layers like buffer/window layers contribute to photogenerate voltage in a solar cell? A larger Voc of 900 mV was obtained owing to the larger band gap of a-Si (Eg = 1.7...

09 August 2019 4,485 4 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

Arena simulation - how do i model the following model in ARENA (see description) (new to ARENA)?

Hello, I'm fairly new to ARENA and I have the following problem: I have two queues in which, in each queue, a different order type arrives (both having an arrival rate of exponential 10). Order...

02 March 2021 2,431 3 View

No title

02 March 2021 3,060 3 View

Why are the velocities so high in my Boussinesq approximation Fluent simulation?

Hello, I have a mechanism where air rises due to convective flows. In this simulation, nothing is driving the air except this. I understand that the Boussinesq approximation only works for small...

02 March 2021 4,910 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View