Tumor differ from normal tissue in their mechanical properties , stroma of breast cancer as example is stiffer than those of normal tissue , now do we have available pharmacological technique or amenable to develop that can be activated or release their contents at degree of stiffness exist in cancer but not normal tissue.
I think that this unique property may offer a way for drug delivery specification at least theoretically.
However , i know little about about utilize of nanotechnology in drug delivery and diagnosis but i think it can be utilized in this situation.
somewhere i have gone through that cancerous cell have higher temperature than the normal cell. by using that mechanism, if we prepare the temperature sensitive drug delivery system that will releases the drug at that temperature, but not at the normal body temperature. like wise we can utilize that concept and formulate novel drug delivery system without harming normal cells.
Some studies related to cancerous cells supports that pH of the environment will becomes acidic. So there is a possibility of developing a pH responsive drug delivery system. (Please check literature related to this)
Utilising Nanoparticletweezers coupled with Radio sensitizers can help for your
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