We are aware that T cells can specialize into various memory cell types, such as stem cell memory (Tscm), central memory (Tcm), effector memory (Tem), and resident memory (Trm) subsets. However, the intracellular signaling regulation involved in the differentiation of these subsets appears to be less understood. Are there any evidence indicating important signaling pathways or key factors that might influence or determine the generation of specific memory cell subsets?
Hi Arthur Gomes
Please consider the the hematopoietic defects (in mice & humans) associated with loss of function mutations in Mysm1 and Slfn2 that impair quiescence in the CD8 T cell compartment that do result in activation phenotypes as defined CD62L, CD44, CD69 etc. typically used to define effector/ memory T cells (at a superficial level).
For MYSM1 related papers consider:
Article The critical role of histone H2A-deubiquitinase Mysm1 in hem...
Article Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19ARF/...
Article A role for the histone H2A deubiquitinase MYSM1 in maintenan...
And for SLFN2 please see:
Article A Slfn2 mutation causes lymphoid and myeloid immunodeficienc...
Article SLFN2 protection of tRNAs from stress-induced cleavage is es...
I hope that helps.
All the best & kind regards,
Michael
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