I'm looking for any medical conditions that trypsin concentration significantly increases in the disease state. Any information on the concentration of trypsin in normal environment versus disease condition will be great as well.
James Leigh, although an interesting thought, it is my understanding that A1AT deficiency doesn't lead to increased trypsin but please feel free to correct me! In A1AT deficiency, certain gentoypes of the A1AT gene mean the protein is malformed and unable to be transported from the liver to, for example, the lungs. As a result there isnt sufficient A1AT to break down neutrophil elastase in the lungs, leading to an increased risk of disease such as COPD (emphysema).
Immunoreactive serum trypsin in diseases of the pancreas
http://www.ncbi.nlm.nih.gov/pubmed/522426
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