Dear Colleagues,
To design a final stage process development for lipid nanoparticle formation using microfluidics, what aspects should be taken into account? Thank you for your suggestions.
Sincerely,
Jacky Tsai
@ Jacky, high pressure homogenization is needed in final stage and maintenance of pH is very essential as it is very pH sensitive.
Jacky Tsai
The sequence of manipulation of fluid technology depends on the problem you want to solve. For the synthesis of nanoparticles, core-shell nanoparticles, polymer balls ... the instructions of the companies that produce the devices are different.
Molinaro, Roberto, Michael Evangelopoulos, Jessica R. Hoffman, Claudia Corbo, Francesca Taraballi, Jonathan O. Martinez, Kelly A. Hartman et al. "Design and development of biomimetic nanovesicles using a microfluidic approach." Advanced Materials 30, no. 15 (2018): 1702749.
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