which company/institute make scaffolds with controlled growth factors release ?
have any hospital or clinical trial used of this approach for tissue repair?
There are two scaffolds releasing growth factors for bone: (i) INFUSE by Medtronic, releasing BMP-2, and (ii) OP-1 by Stryker, releasing BMP-7. However, despite being already in the market, they are being re-evaluated by the FDA due to several side effects related specially to BMP-2, raising concers about the use of growth factors in vivo.
Take a look at this paper: Spine J. 2011 Nov;11(11):1082-3; author reply 1083-6. doi: 10.1016/j.spinee.2011.09.029
Cheers!
Dear Etezadi,
As Dr. Sánchez-Ferrero stated there are these two products in the market InFUSETM Bone Graft/LT-CAGETM (Medtronic) a collagen sponge impregnated with human recombinant BMP-2, Osteogenic Protein-1® also indicated for the treatment of bone fractures being composed of BMP-7/collagen paste (Stryker Biotech). I would just add REGRANEX® Gel (OMJ Pharmaceuticals) human recombinant platelet-derived growth factor sequestered in a hydrogel for the treatment of diabetic foot ulcers.
I would suggest you: "The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions", as well as "Clinical translation of controlled protein delivery systems for tissue engineering".
Hope it was helpful!
Warm regards,
Daniela
Dear Aitor Sánchez-Ferrero and Daniela P. Pacheco
tnx for your kindly respond, all of information that you give are really helpful for my question...
best regards
Dear Etezadi ,
it is of course a promising technology . Daniela and Aitor give us the current situation on the Market. We didn't use it in our clinical research for two reasons :
TE achieved a cascade of events to conduct to regeneration of tissues . this is dependant to the biological action of many GF , inducing cross talk between cells: so using only one for clinical applications have to be proved ( efficacy /toxicity) with supra physiological concentrations use
technology of PRF ( autologous Platelet Rich Fibrin) allows slow release of multiple GF , furthermore this product works like a sponge and other biological products can be added ( see PRF to Medline)
hope that it is helpful
best regards
Pierre
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