If microRNA comes from intervening sequences, its reaction of any mechanism or its itself generated body defence mechanism? Means its reaction of body process in disease creation stage or cellular stage of generation of microRNA?
Maulik:
Intronic miRNAs are a new class of miRNAs derived from the processing of nonprotein-coding regions of gene transcripts, and are processed from the introns of their hosting transcription units and hence share common regulatory mechanisms and expression patterns with their host gene; thus, they regulate gene expression and are able to induce RNA interference (RNAi), and they in a sense "fine-tune a variety of cellular and developmental events through the mechanism of RNAi-like gene silencing1-3.
Thus, three critical functions are involved:
References:
It has been reported that an intronic miRNA, transcribed along with the host gene mRNA, might silence several genes, which antagonize the function of host gene itself, thus serving the interests of the host gene. Thus it can help the cell function physiologically when faced with cellular perturbations, and can have a regulatory role in modulating human diseases.
Maulik:
Intronic miRNAs are a new class of miRNAs derived from the processing of nonprotein-coding regions of gene transcripts, and are processed from the introns of their hosting transcription units and hence share common regulatory mechanisms and expression patterns with their host gene; thus, they regulate gene expression and are able to induce RNA interference (RNAi), and they in a sense "fine-tune a variety of cellular and developmental events through the mechanism of RNAi-like gene silencing1-3.
Thus, three critical functions are involved:
References:
Dr. Maulik Rachh
microRNA, also known as miRNA, are 20-25 nt long genome-encoded RNA molecules which are involved in mRNA regulation either by its repression or degradation. They are located mostly in the intergenic (intron) regions and widespread among organisms. Recently, they have gain particular interest in cancer as biomarkers.
I suggest you to read the recent paper published in Biotecnología Aplicada on this topic, by Dr. Alejandro Moro, entitled: MicroRNAs as biomarkers and therapeutic targets in cancer. Their properties, discovery, genomic structure, nomenclature, biogenesis, mechanisms of action and use as biomarkers in cancer are further described.
Please, find attached the paper and I hope this would help on your research.
Sincerely
Ernesto Galbán Rodríguez
Editor
Elfos Scientiae Publisher
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