I am developing HIV Viral Load Detection Assay, in that my Quantitative Standards are in Copies/mL, but I want to convert it to International Unit (IU)/mL as WHO recommendation to give results in IU/mL only.
Is there any Standard Formula for the same to convert Copies/mL to IU/mL?
As much i know there is no standard value for the same, we need to derived from HIV WHO Standard available at NIBSC which provides IU/mL concentration value. But How to convert it ?
Hi,
If you are speaking about HIV viral load, HIV viral load results are not usually expressed in IU. But, the general IU conversion factor is 1.74 copies/IU, or 71,000 IU.
Hope this helps.
Daglous Gesora Thank you for your answer. Can you please help me with any reference literature if you have? Because i need to prove it to License authorities with reference paper. Thank you.
Hi Maulik Rachh Am able to find one which says the general IU conversion factor is 1.72 copies/IU.
Check out page 20 of this document
According to the attached document from WHO. (1 IU=0.58 copies, 1 copy=1.74 IU).
https://www.who.int/diagnostics_laboratory/evaluations/pq-list/hiv-vrl/170830_amended_final_pr_0145_027_00.pdf
Daglous Gesora Is the conversion factor dependent on the extraction procedure that you used or is it so general value?
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