In adults with CT scan evidence of liver injury (due to BAT) ,is there a corresponding alteration in hepatic transaminases and how long do they remain altered.
hepatic transaminases are almost always altered in a liver blunt trauma. How mach higher would be the increase and how long this condition will remain depends from the grade of the liver trauma (Injury Severity Score) and the eventually angiographic embolization of a evident blush. The time for a secure NOM (non operative management) varies from one to three weeks, and sometime we discharged the patient with transaminases not yet normalized
Dear Giorgio Vasquez, thank you for the answer.however i feel that there is only very little evidence from literature about altered level of liver enzymes in traumatic liver injury.
Absolutely. A bit of brushing up of biochemistry: both SGOT/AST and SGPT/ALT are intracellular liver enzymes which actually indicate the integrity of the hepatocyte. Any damage to the hepatocyte whether it is medical or surgical
Yes Abraham Ittyachen M ·,but is there any study depicting his phenomenon in traumatic liver injury in BAT victims[adults] and how does i correlate with CT findings..
I am not sure about the relationship between the severity of the liver damage and the level of the increase of the transaminases.Is there any evidence of that?
The levels of liver enzymes elevation depents absolutely from the severity of liver or abdominal trauma and generally from the hemodynamic situation of patient. AST elevation could be elevated in any trauma, given that thiw enzyme is derived also from mascular tissue. ALT ,as unique liver enzymes, is increased either as a result of direct hepatocellular damage (trauma), or as result of ischaemic (bood loss) hepatocellular damage.
how many articles have cited the evidence of altered hepatic enzymes in liver trauma-
The greater the degeree of blunt trauma to the liver the greater the likelihood of patient death and/or morbidity. This is largely due to haemorrhage followed by infection occurring in devascularised portions of the liver.
From what I am aware the levels of the liver enzymes in the first instance are not what guides treatment but rather patient haemodynamics and CT scan findings (plus arterial phase imaging if necessary via angiography).
Hence why you may have trouble gaining a precise answer from scanning the literature.
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