I would like to know about Type II collagen biosynthesis, native structure and stability and their difference from Type I collagen. Does anyone have info regarding this?
Look to the differences in glyconutrient compositions. For example, a common deficit in Rheumatoid Arthritis is the absence of galactose. See Bagchi D, Downs BW, et al. "Effects of Orally Administered Undenatured Type II Collagen Against Arthritic Inflammatory Diseases: A Mechanistic Exploration". Int. J. Clin. Pharm. Res. 2002;22(3-4):101-10
Thanks Bernard......I am looking on the structural aspects and its ability in fibril formation compared to that of type I collagen. I came to know about few of the points like 1. Its highly glycosylated. 2. thinner fibrils than type I collagen.
Hi there..Type II collagen is also highly hydroxylated hence the cross-links are predominantly keto-amine (HLKNL) and its maturation product Hyl-Pyr.
I'd say also that Collagen type II consists of 3 identical alpha chains, while collagen I is a heterotrimer with two identical alpha chains and a third distinct chain. In addition, Collagen II is covalently cross-linked to both collagens IX and XI in the cartilage fibril, through lysine-derived cross-links (type II-rich fibrils frequently contain
types IX and XI collagen).
Good luck!
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