Last time I checked the Roche 480 LightCycler made this possible, but it was near impossible to pipette the 1536 plates.... The question is, is there any way to address individual positions (a one-er pipette tip on a gantry robot, for instance) that can actually save money in the lab AND provide high individual PCR throughput? Yes, I know about Fluidigm. Not exactly the same thing. Here is a recent review and I don't see the kind of robotics I am thinking of: http://www.labtimes.org/labtimes/issues/lt2010/lt01/lt_2010_01_54_57.pdf
Is there anything new on this front?