nowadays there is increased use of sofosbuvir with or without ribavirin or interferon, little is known about respiratory side effects and if these effects are strengthened by ribavirin or interferon combination dose anyone has experience.
Dear Dr. Eman Sobah: The http://www.drugs.com/sfx/sovaldi-side-effects.html has listed all the common side effects of Sovaldi (sofosbuir) which include fatigue, headache, nausea, insomnia, itching, anemia, weakness, rash, decreased appetite, chills, flu-like illness, fever, diarrhea, joint pain, and irritability
They also list some respiratory problems (10% or more): dyspnea, cough
Common (1% to 10%): Nasopharyngitis, exertional dyspnea etc.
since it is a 5Fluoro-Uracyl -like compound albeit with far lower side effects, all side effects listed for 5-FU are likely to appear in some instances. In particular, it is more likely in individuals with impaired mitochondial respiration, low intracellular Calcium (check PTH NOT serum Ca++), anemia (most cirrhotics), AND comorbidity. I check liver iron stores by SQUID (luckily we have the machine!),30-40% of our cirrhotics -Europeans- have liver iron accumulation by this methodology; alpha1 antiptrypsin heterozygosity, elevated chloride in sweat (10%) ( subclinical CFTR-related disease? ). Most viruses carry proteins interfering with mitochondria: flu and Adenovirus are typical. Hpylori p34 subunit of Vac-A is a toxin for mitochondria, Hpylori toxins include cytodistensive hepatocyte toxin. As to food and water: water disinfection methods generate over 600 possible toxins including chloroform (29microg/L), trihalomethane, haloacetic acid, nitrosamines. Levels of methotrexate and cancer treating drugs in the lake near Geneva and in river in large European cities reach theratogenic levels. FDA reports that 45% of all food purchased in stores in the 252 sentinel counties in the USA contains more than the allowed level of toxic chemicals, necessary for crop production. Fresh "healthy" food is the most dangerous (salad, celery, berries, apple and so on ) Aflatoxins are not found solely in Asian in African countries.
Below are two papers addressing your question. There were incidents of upper respiratory infection, but few other adverse respiratory effects. One paper deals with genotype 1 HCV and the other genotype 4 HCV. Let me know if you need more sources. Happy to help.