Joseph Gosnell

11 Questions 82 Answers 0 Followers

Questions related from Joseph Gosnell

Why is there a difference in prevalence between B-cell and T-cell Lymphoma?

I was posed a question by a hematopathologist in training this morning: Why are B-cell lymphomas more prevalent than T-cell Lymphomas? My initial guess was perhaps there is increased tolerance...

20 November 2020 2,625 4 View

Any advice in using AFP as a delivery tool for anti-neoplastic therapy?

I have been reading about the theoretical use of AFP (alpha-fetoprotein) in the delivery of chemotherapeutic agents to neoplasms that express AFP receptors (i.e. hepatocellular carcinoma, breast...

03 December 2015 1,989 0 View

Any advice on analysis with GCMS-MS Specs to pair with Electrocautery for Phospholipid Analysis?

I am interested in experimenting with iKnife-like systems. I need to know what column would work best to analyze phospholipids in a GCMS-MS system. This would be, primarily, used to determine...

28 September 2015 326 7 View

Any suggestions about cell-based artificial liver or dialysis-based?

Do you think the future of artificial liver research is headed toward cell-based efforts or dialysis-based efforts? Perhaps a combination of the two? Efforts like MARS and Prometheus are...

17 June 2015 8,659 7 View

Can I get an explanation of the benefits of Vertical Integration v.s. Horizontal Integration in Conglomerates?

I am beginning the foundation work for, what I hope to become, a conglomerate in various industries (medical, real estate, multi-media, tech. to name a few). Could anyone provide arguments for...

17 May 2015 2,812 16 View

Why does ELAD cause thrombocytopenia?

Extracorporeal Liver Assist Device (ELAD) was shown to cause thrombocytopenia in clinical trials. Obviously, this is an unwanted side effect and could worsen the already compromised hematological...

16 May 2015 4,311 10 View

What metabolomic methods would be recommended for determining cell-cell signaling in the liver?

I am working on a project to determine which cell-cell signals/metabolites are important in the three-way communication between Hepatic Stellate cells, Kupffer cells, and hepatocytes within the...

05 May 2015 7,910 3 View

What are the plastics requirements for Extracorporeal Liver Assist Device (ELAD)-like devices?

I need suggestions on plastics that fit the following requirements, please. 1) Can be used in a 3D Printer (preferably MakerBot 5th Gen. Replicators) 2) Can be used for adhesion of collagen to its...

19 April 2015 7,923 1 View

Does anyone know why albumin dialysis, ELAD, and other bioengineering efforts at liver dialysis are not gaining wider usage as a bridge to transplant?

All the articles I find about clinical trials for both albumin dialysis and ELAD (extracorporeal liver assist devices) show positive results and have even successfully bridged the gap to...

31 March 2015 1,699 21 View

Does anyone have some good reference material for Hepatic Stellate Cell cultures?

I am working with some Hepatic Stellate Cells (HSCs), but I need some more information on culture maintenance, materials for optimal growth, etc. I have read several papers, but I was wondering if...

20 January 2015 8,134 4 View

Disulfide by Design User Feedback

Hello, I am helping do some research into use for this disulfide prediction software in both pharmaceutical peptide research and industrial chemical applications. Anyone interested, could you...

01 January 1970 6,842 0 View