I am trying to decipher the effect of some compounds at the level of chromatin condensation. I have looked at relaxing chromatin with HDAC inhibitors (eg TSA, VPA), which has proven to work very nicely. However, I am struggling to find any drugs that can produce the opposite effect. Any ideas on what to use?
I have looked into HDAC activators, but there are very few and generally work for a specific subtype of HDAC.
Many thanks!