Need an effective way to obtain curcumin from the plant extract
Plz find some patents and CO2 Supercritical Extraction method for organic grade of it
Method for isolation of curcumin from turmeric :
- Extract about 50 g of turmeric powder with 95% alcohol in a Soxhlet assembly until all the colouring matter is extracted.
- Distil off alcoholic extract to a semi-solid brown coloured mass (about 4.5%).
- Dissolve the crude extract in 50 ml of benzene, and extract twice with equal volume of 0.1% sodium hydroxide solution.
- Combine the alkaline extracts and acidify with dilute hydrochloric acid. A yellow coloured precipitate is formed. Allow it to settle for about fifteen minutes.
-After setting of precipitate, concentrate the extract by boiling on water bath and at the same time dissolving precipitate in boiling water. During this process of boiling, the resinous material would agglumerate and form lumpy mass.
- Filter the solution in hot condition and concentrate filrate to very small volume and finally cool to get curcumin (15%).
Curcumin is an orange-yellow crystalline powder with m.p. 183°C.
Reference
Kokate, C. K. (1994). Practical Pharmacognosy, Vallabh Prakashan. New delhi, 1, 3.
Article Isolation of Curcumin from Tumeric
.https://www.researchgate.net/profile/Ali_Aldallal2/post/What_are_the_critical_factor_that_affect_curcumin_synthesis_in_turmeric/attachment/59d632ce79197b807799080c/AS%3A371845695066112%401465666330246/download/Isolation+and+synthesis+of+curcumin.pdf
https://www.mdpi.com/1420-3049/19/12/20091/pdf
Article Curcumin: A Review of Its' Effects on Human Health
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