hmmm... but then if I were to test that in vitro via MIC testing, be it an automated system/ BMD/E test I would not induce Amp C right for those that carry this in their chromosomes.. as Such wouldn't that be dangerous to use ceftazidime for this patient when the ceftazidime is not used for other organisms that are known to carry this enzyme.. i.e. citrobacter/ enterobacter.. My hospital will add a comment saying that amp C can be induced for the above organism and carbapenem is preferred but the same comment is not given when Pseudomonas is detected.. Why so... I know ceftazidime is a low inducer for amp C but wouldn't one use this for other SPICE organisms then ?
Good question. Statistically, in the clinical situation it is not more likely than in ~10% and probably less likely than to select out an ESBL-producing strain. Low induction is a posible explanation.