Insulin regulates cerebral glucose homeostasis through insulin receptors which require mitochondrial H202 production to activate. Can a t2d state of hyperinsulinemia cause excess H202 and cause mitochondrial dysfunction?
Research OPTIMIZATION OF FLOATING HORIZONTAL AXIS WIND TURBINE (FHAWT...
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Kindly see the following article:
Article Insulin Resistance and Oxidative Stress in the Brain: What’s New?
See also the following article:
Article Oxidative Stress and Metabolic Syndrome: Cause or Consequenc...
Also, see the following link:
https://www.frontiersin.org/articles/10.3389/fmolb.2021.651215/full
The following article may also helpful in this regard:
Article Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease
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