You need to perform a rule of three.

2g extract _______ 1 Kg

x _______ 500 Kg

x = 1,000 g (or 1 Kg extract)

After, you will need to calculate the amount of extract based on the administration route. In water, you will need to know how much water per day the animal drinks. After, add the amount you want (e.g.,1 kg) in this volume, to assure the daily dosage. For diet, you follow the same idea, based on food intake/day.

Here is an example of diet dose calculation:

https://researchdiets.com/opensource-diets/add-test-compounds/diet-dose-calculator

It is crucial to follow daily water (or food) intake to assure that the dose that you planned was actually ingested.

Dr Caroline. Thanks

You are welcome. You can also see this work that we have made available recently in bioRxvi: https://www.biorxiv.org/content/10.1101/615567v1

Dr Caroline, much appreciated.

2 to each 1Kg body weight

you need to 1000 g to animal with 500 kg

2g 1 kg

X 500

Thanks to Dr Mohanad.