How long can AAV 2 or 9 be stored at -80 C and used for intracranial injections before it needs re-titre?. Meaning...how fast will it degrade or become less viable.
We often used AAV that have been stored -80 °C for more than a year, and the infectivity is very good. We also detected the titer and find no significant decrease. So, our experience is that there is no problem to store AAV for one year.
You could find more information about AAV production and application in this website: https://www.genemedi.net/i/aav-packaging
With our years of experience in packaging AAV virus, the adeno-associated virus is stored at -80 ° C and avoids repeated freezing and thawing. It can be stored for about 1 year without problems. If you store for one year, it is recommended to measure the titer and then do the infection.