In trying to getting more effective neoantigens for cancer therapy, I have some questions as followings.
1. T-cell activation is considered to be more important than B-cell activation. Which type of T-cell is more impotrtantbetween CD8+ T-cell and CD4+ T-cell? And what is the reason?
2. If a neoantigen have an activity for B-cell activation (i.e. for antibody production), does it have also the activity for T-cell activation?
If not, it is considered there are no correlation between them. Is it right?
Your answers would be very appreciated.
from DM
1. Between CD4 or CD8, most would say CD8. First, CD8 recognize MHCI presented antigens, which all cells can present, thus they can have direct cancer cell activity. Also, most CD8s are cytotoxic, and can kill targets. CD4 is restricted to MHC II presented antigens and mostly are helper Ts. They direct immune response, but may not interact directly with targets as easily as CD8s.
2. B cell activation and antibody production isn't exactly without T cell help. Unless the antigen is strong enough to induce B cells to isotype switch without CD4 T cells... antibody production is still dependent on CD4 T cell recognition of antigen.
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