Metabolic Diseases

Is targeting thermogenesis a viable treatment option for obesity/metabolic disease?

Overexpression of uncoupling proteins in small rodents is an effective way to alter thermogenesis. This strategy prevents diet induced obesity and insulin resistance (link 1). There is now...

11 December 2014 1,277 10 View

Which one of databases do you recommend to explore validated targets for miRNA categorized by disease/metabolic disorder?

Which one of databases do you recommend to explore validated targets for miRNA? I'd like to know, if there are targets for one specific miR connected with cholesterol and lipid...

25 November 2014 8,851 2 View

Which type of insulin should be used to carry out Insulin Tolerance Test in type 2 diabetic rats?

I have induced type 2 diabetes mailitus using high fat diet (45% fat) plus multiple low dose of streptozotocin (30mg). So can any please tell me Which type insulin (Short, log, Intermidiate acting...

25 November 2014 5,489 13 View

Do you think that hyperlipidemia may be intermittent?

Apart from the effects of dietary changes and variable therapeutic compliance,do you know if there are other sources of comorbidity (apart of diabetes, thyroid status and cholestasis) that may...

14 October 2014 6,452 4 View

What exactly is the role of insulin in insulin resistance?

The role of hyperglycemia, saturated fatty acids, oxidative stress, inflammatory cytokines have been investigated in causing insulin resistance. However, is hyperinsulinemia itself not likely to...

18 September 2014 785 34 View

What is the difference between the prevalence of insulin resistance found in those with NASH versus those with Hepatitis C?

NAFLD shares many overlapping features with the insulin resistance syndrome, also known as "Syndrome X" including central or visceral obesity, type II diabetes, and dyslipidemia. Of course, NAFLD...

15 September 2014 968 5 View

How can we characterize healthy elderly?

When studying some metabolic parameters in elderly people, it seems difficult to distinguish which ones are caused by aging per se or by age-related diseases. In particular, circulating IL-6 is...

20 June 2014 5,466 5 View

Can anyone suggest an easiest/efficient method for the estimation of IL-18 in atherosclerotic animal models or from serum?

IL-18 is specific bio-marker of metabolic syndrome.

16 April 2014 7,964 3 View

What is the most popular herb or plant derivative that is mainly used for the treatment of diabetes in your country?

Diabetes is a group of metabolic diseases in which a person has high blood sugar. This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger....

05 April 2014 666 13 View

What is the current status of laparoscopic jejuno-ileal bypass for Diabetes mellitus (DM) control in patients with a BMI < 30?

Several dedicated centers have published data regarding this, but our diabetology friends beg to differ. Any (unbiased!) thoughts?

02 April 2014 8,004 8 View

Is there any explanation for lower insulin and higher laccate levels after propionate injection?

I found that lower insulin levels were associated with higher lactate levels.

10 October 2013 2,946 2 View

What is the blood pH and HCO3 level of ascites syndrome broilers?

Is there any publication that contains this data?

07 January 2013 2,113 2 View

Does anyone have experience in the nutritional management of severe organic acidemia?

We have a 9-old month infant with high level of blood Glycine. Urine for organic acids showed high levels of methyl malonic acid,, increased 3-OH-propionic acid & methyl citric acid. She has...

14 September 2012 2,657 3 View

What are the growth phase or metabolic activity of most bacteria in the gut?

Gut microbiota play significant roles in human health. With the help of Next-gen sequencing, we know much about the compositions of bacteria in the gut but little is known about their activities....

01 January 1970 2,712 3 View

Can the glucose over load that used for treating acutely unwell children, known to have metabolic disorder, result in diabetes in the future?

Treating children known to have metabolic disorders often includes ensuring adequate amount of calories for age and weight to avoid catabolism, that is usually by giving glucose solution 10%. What...

01 January 1970 669 7 View

What are the growth phase or metabolic activity of most bacteria in the gut?

Gut microbiota play significant roles in human health. With the help of Next-gen sequencing, we know much about the compositions of bacteria in the gut but little is known about their activities....

01 January 1970 6,258 3 View

Are metabolic diseases linked with each other?

According to common soil hypothesis metabolic diseases are associated with each other due to underlying insulin resistance. What is your take on that?

01 January 1970 5,510 20 View

Is high fat (lipid) intake the major causes of coronary heart disease, obesity and type 2 diabetes or high sugar (Sucrose = Glu + Fru) drinks?

Please go through these 3 references: 1. An excerpt from wikipedia: (https://en.wikipedia.org/wiki/Lipid) reads: "A few studies have suggested that total dietary fat intake is linked to an...

01 January 1970 5,330 36 View

How can physical health be better addressed in people living with severe mental illnesses?

Anecdotally, much of the healthcare provided to people living with severe mental illness focuses on their mental health, negating physical health concerns including chronic disease. The...

01 January 1970 9,887 11 View

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01 January 1970 3,969 0 View