Is there any explanation for lower insulin and higher laccate levels after propionate injection?

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Victor Calvo-Perez

Lactate? High CH3CH(OH)-COO levels means CH3CH2COOH has been hidroxylated. Something different has been reported long ago.

British Journal of Nutrition (1990), 64, 95-101

Yannis Karamanos

Having no details about the physiological situation you work, I can only speculate : logically, propionate is absorbed and metabolised after conversion to propionyl-CoA which in turn produces succinyl-CoA. If no glucose is added to the diet, the insulin level is low and it is necessary to restore the level of glucose in the blood by activating neoglucogenesis. Thus the succinyl-CoA is used in the Krebs cycle, to produce oxaloacetate which, thanks to the shuttles, can go back to the cytoplasm and contribute to neoglucogenesis. But this cannot explain the level of lactate.

Is it possible to have more information about the overall context ?