Inherited metabolic disorders are genetic conditions that result in metabolism problems. If it's can considered as linking so most people with inherited metabolic disorders have a defective gene that results in an enzyme deficiency. There are hundreds of different genetic metabolic disorders, and their symptoms, treatments, and prognoses vary widely.

Inherited metabolic disorders are genetic conditions that result in metabolism problems. If it's can considered as linking so most people with inherited metabolic disorders have a defective gene that results in an enzyme deficiency. There are hundreds of different genetic metabolic disorders, and their symptoms, treatments, and prognoses vary widely.

Dear Karen A. Darbinyan Milan B. Vemić

Thanks for your valuable input. Common soil hypothesis basically deals with insulin resistance as the key cause which leads to multiple metabolic derangement starting from obesity to diabetes and hypertension.

So what do you actually think now of insulin resistance being the linker between all the diseases?

regards

Genetics omitted. Do not forget in these branches, virtually all have one or more related connections with genetics. In fact, today epigenetics has it mostly associated with obesity through DIETARY CHANGES, not just dietary and lifestyle changes. Sometimes, it is genetic drift and not initiation from dietary changes. Even though, control of these pointed ground initiators may still predispose one to the diseases through mutative drive.

We all know the impact of genetics in DM, hypertension and co. And most importantly, almighty cardiovascular not included.

Dear Kamoru A. Adedokun

Very true. In fact genotype phenotype linkage is very essential in this incoming time of molecular medicine.

Thanks a lot for adding this to discussion.

Regards

Inherited metabolic disorders are genetic conditions that result in metabolismproblems. Most people with inherited metabolic disorders have a defective gene that results in an enzyme deficiency. There are hundreds of different geneticmetabolic disorders, and their symptoms, treatments, and prognoses vary widely

https://www.webmd.com/a-to-z.../inherited-metabolic-disorder-types-and-treatments

Metabolic syndrome is a group of conditions that make a person more susceptible to heart disease and diabetes, also called metabolic syndrome, insulin resistance syndrome and X metabolic syndrome. Insulin resistance usually occurs with other health problems such as diabetes, high cholesterol and high blood pressure, all of which are risk factors for heart disease. This is why metabolic syndrome is called insulin resistance syndrome.

Thank you for your valuable comments Afraa Ibrahim Nirmala S.V.S.G

Following

A metabolic disorder happened when abnormal chemical reactions in the body alter the normal metabolic process. It is inherited single gene anomaly,and the diabetes is the example of metabolic disorder.

There are some links i studied over last 2 days. It is rather important to understand this concept as not knowing the baseline origin i.e., insulin resistance will result in usage of appropriate drugs therapy and multiple elements can be helped by this approach and vice versa. The reference i gather are as below:

Article Is Oxidative Stress the Pathogenic Mechanism Underlying Insu...

This article by Ceriello et al suggested following " This hypothesis, moreover, may also contribute to explaining why treating cardiovascular risk with drugs, such as calcium channel blockers, ACE inhibitors, AT-1 receptor antagonists, and statins, all compounds showing intracellular preventive antioxidant activity, results in the onset of new cases of diabetes possibly being reduced."

Other references include:

Article Drugs share antidiabetic and antiatherosclerotic actions thr...

Article Comparing the inflammatory profiles for incidence of diabete...

Those interested in this hypothesis may be benefited by these articles

Regards

Are the metabolic diseases illustrated in the figure linked to each other? Yes, I think so. Many studies have demonstrated their positive correlation. In fact, as mentioned in certain replies, some of these metabolic dysfunctions, namely, central obesity, high blood glucose, dyslipidemia and high blood pressure, are clustered and termed as "metabolic syndrome", which is generally considered as a pre-morbid medical condition. People with metabolic syndrome are significantly predisposed to type 2 diabetes mellitus, cardiovascular diseases among some other chronic diseases. Therefore, there is almost no doubt that these diseases are linked to each other and may share very similar pathology.

However, saying that insulin resistance (or oxidative stress) is the root of all these disorders is likely to be incorrect. If insulin resistance is indeed the underlying cause for all the aforementioned diseases, improving insulin sensitivity should cure them. In clinical settings, the effects of insulin sensitizers like thiazolidinediones on diseases like hypertension and cardiovascular disease are marginal. Likewise, therapy with antioxidants also failed to yield clinical significance in these chronic diseases. Hence, insulin resistance and oxidative stress may play a key role in exacerbating the metabolic dysfunction, but they are unlikely to be the only factors.

In fact, hypothesis about the underlying mechanism of these chronic diseases has been slowly shifting from insulin resistance-centric to obesity-centric, which I think is a better hypothesis. Over-consumption of high energy foods leads to high caloric intake which leads to obesity. Without an active physical lifestyle, the body cannot accommodate the high influx of energetic metabolites, causing the regulatory system (eg. insulin) to go haywire. This hypothesis suggests that no single drug can successfully reverse the metabolic diseases unless coupled with lifestyle modifications.

On the other hand, if you are interested, check out bariatric surgery. It is a surgical method that could help to improve or even reverse type 2 diabetes. I would call it a shortcut.

All factors of metabolic syndrome are related each others and overlap. Otherwise, some factors more dominant than others, depends on generic and environment risks.

Not true for all cases.

Yes. For example, diabetes mellitus is an endocrine driver for metabolic crisis.Carbohydrate, protein and lipid metabolic pathways are all affected.This means that diseases associated with carbohydrate metabolism, protein metabolism and lipid metabolism will manifest. Pathways are Integrated and what affects one has consequence on another. Consider obesity and diabetes and the associated pathways.

Absolutely!

Very simple:

Near constant eating --> Insulin always high --> No chance for autophagy.

That oversimplification probably accounts for at least 70% of all disease (when you trace autophagy as a cause of inflammation).

Simple: if you never take out the trash, what happens?

If you never took the trash out in your home, over the course of many years, would only some types of furniture suffer?

Yes, the tree speaks of metabolic syndrome as a body.

I thought I would add a corresponding diagram used by the anti-aging community. These causes of aging represent a kind of tree trunk divided into six distinct mechanisms of loss of health. These are all being targeted to extend healthspan and, to a lesser extent, lifespan. Any chronic disease can be mitigated or delayed or prevented by working on any of the pathways shown.

I'm a fan of the Buck Institute for Aging near San Francisco.

https://www.geripal.org/2019/10/geroscience-and-its-impact-on-human.html

Metabolic diseases are linked with each other but manifestation is occurring slowly. Most important root cause of the metabolic diseases is chronic impairment of overall digestion.

No. because there are two metabolic disease which are differ from each other

1. Genetic metabolic disease disorder

2. Nutritional metabolic disease disorder

to some extend might each one has affect on metabolism of nutrient