Currently, I work in a lab that does research on Diabetes, Atherosclerosis, and Osteoporosis. I am the research specialist and am not involved in the hypothesis or theory of our project, I am just the technician. However, I love to read and learn more about our project and how it can be applied in other fields. In on our models we will be studying the mechanisms of S1P related to the disease models I mentioned earlier. I am just curious how or why you would be studying these interactions and if there is a future implication for human health or if it just a biological question. Would you have time to refer me to any literature? Or, If you have time to merely answer the question that works too! Thank you for your time and I wish you the best in your research!
Sphingolipids are bioactive molecules that may be found in circulation associated with either plasma proteins (eg, albumin) or lipoproteins (eg, S1P). S1P has been reported to be at least partly responsible provide anti-apoptotic and anti-inflammatory properties to HDL and exert anti-atherogenic effects as revealed in mouse models. S1P can be synthesized intracellularly and may act by means of autocrine and paracrine mechanims via interaction with S1PR's onto the own cell or neighbors. Potentially, this compound may also reach other parts of the organism transported by lipoproteins or albumin. I enclose some works reviewing favorable effects of S1P on inflammatory diseases. I hope they will be of help or may be an starting point for you. With kind regards.
I am a PhD student in my first year working in a lab that searching for naturaceutical as a therapy for atherosclerosis. For example my project is on Pinolenic acid (PNLA) as PUFA have anti-atherogenic action on LDL, monocyte migrations etc... in vitro. Following this going to work on mouse model to see the effect of PNLA on atherosclerosis
. Regards Sphingolipids I have no idea really. Thanks Joseph for providing an answer. As soon as I finish my mini viva and getting more results I ll plot any update . Thanks all and best wishes.
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