For example, under what circumstances should we add evolution?
Does it have to be multi-scale problem?
How to determine if evolution plays a big role in the disease models?
Dr. Ding,
maybe this reference can interest you:
-MacLean, R. C., Hall, A. R., Perron, G. G., & Buckling, A. (2010). The evolution of antibiotic resistance: insight into the roles of molecular mechanisms of resistance and treatment context. Discovery medicine, 10(51), 112-118.
Abstract
The widespread use of antibiotics has markedly improved public health over the last 60 years. However, the efficacy of antibiotic treatment is rapidly decreasing as a result of the continual spread of antibiotic resistance in pathogen populations. The evolution of antibiotic resistance is an amazingly simple example of adaptation by natural selection, and there is growing interest among evolutionary biologists in using evolutionary principles to help understand and combat the spread of resistance in pathogen populations. In this article, we review recent progress in our understanding of the underlying evolutionary forces that drive antibiotic resistance. Recent work has shown that both the mechanisms of antibiotic action and resistance, as well as the treatment context in which resistance evolves, influence the evolution of resistance in predictable ways. We argue that developing predictive models of resistance evolution that can be used to prevent the spread of resistance in pathogen populations requires integrating the treatment context and the molecular biology of resistance into the same evolutionary framework.
Best regards,
Juanma
Thank you very much! I will check it out.
I also find Perron's lab has their Theme Issue on "Evolution and Drug Resistance" is out in Evolutionary Applications:
http://onlinelibrary.wiley.com/doi/10.1111/eva.2015.8.issue-3/issuetoc
You are wellcome.
In case of interest, you can contact Gabriel Perron here on ResearchGate: https://www.researchgate.net/profile/Gabriel_Perron
Best regards,
Juanma
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