Can anyone suggest me how to initiate my work to develop Alzheimer's in Zebrafish?
You cannot develop disease model for AD per se using zebrafish. Some would even argue that the latest triple TG mouse (app/ps1/tau) is not a good enough model for AD.
You can, however, use zebrafish to investigate certain disease phenotypes that are associated with AD. They are especially useful for looking at AD from the vascular disease aspect, since some zebrafish strains have transparent skin, allowing an excellent imaging of their vasculature or even the entire circulatory system. This could even extend to imaging of the brain neurons firing in their brains, as was reported by a group at HHMI last year.
They could also be useful in studying the aging aspect of AD, since you can follow their development in a relatively short time, allowing you to research on many different ideas in a comparatively short time period.
There are a lot of excellent studies out there in AD field that uses zebrafish as their model. However, their research questions are often very focused, and you would want to be very careful when you interpret your data. Extrapolation of your data to clinical implications would require more support from other preclinical models or even clinical studies. Good luck!
It is not pssible because the so called Alyeimers diseases are very heterogenous entity of many cortical demantia syndromas. The diagnosis is postmortem, pathohystological. The speech, language and ndirect memory deterioration are the dominant clinical signs of this syndromas.... Dr Aloise Alzheimer never spoke about "Alheimers disease"! He described only once patient with atypical pszchotic syndroma (Augusta D).
You cannot develop disease model for AD per se using zebrafish. Some would even argue that the latest triple TG mouse (app/ps1/tau) is not a good enough model for AD.
You can, however, use zebrafish to investigate certain disease phenotypes that are associated with AD. They are especially useful for looking at AD from the vascular disease aspect, since some zebrafish strains have transparent skin, allowing an excellent imaging of their vasculature or even the entire circulatory system. This could even extend to imaging of the brain neurons firing in their brains, as was reported by a group at HHMI last year.
They could also be useful in studying the aging aspect of AD, since you can follow their development in a relatively short time, allowing you to research on many different ideas in a comparatively short time period.
There are a lot of excellent studies out there in AD field that uses zebrafish as their model. However, their research questions are often very focused, and you would want to be very careful when you interpret your data. Extrapolation of your data to clinical implications would require more support from other preclinical models or even clinical studies. Good luck!
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