How to validate image labeling quality within dataset?

Hello, it is about creating a dataset for semantic segmentation with three classes. The problem is that one class dominates with >90% and one class is

18 February 2021 4,254 5 View

Are there any DNA extraction kit from resins?

Hi everyone, I'm looking for a DNA extraction kit or some protocols to obtain the total DNA from resin samples. For this purpose, some studies suggest the use of plant extraction protocol of...

25 October 2020 3,898 3 View

How to calculate the effect size of a mixed models anova (from existing research papers)?

Hi all I'm comparing some research papers for my university. The most studies use a mixed model ANOVA design, but did not specify the effect sizes. 1. Is it possible to (re)calculate the effects...

23 October 2020 5,013 3 View

Antibody : loss of binding at high concentration (beyond saturation) Why?

Hi everyone, It is commonly observed that some antibodies presents a binding saturation curve that goes down at high concentration (at concentration beyond saturation). Does anybody have a good...

20 August 2020 778 5 View

TRP1 deficient yeast strain not growing on 5FAA containing medium?

05 August 2020 3,010 5 View

What would be the ideal number of epoch for my Neural Network?

Hello, If I am training my Neural Network with training data comprised of 908 batches, as the rule of thumb, would 20 epochs for training be sufficient? If 20 epochs are not sufficient, does...

26 March 2020 2,291 6 View

How important is it to set seed in experiments in computer science?

Hello, If I am going to submit my work to a CS conference, and also make my Python code available publicly, is it absolutely necessary that I set seed in my Python code? I ran an experiment, but...

07 March 2020 1,832 3 View

How to process ARC dataset with GTP2 Double Heads Model?

Hello, I am interested in processing the ARC dataset (http://nlpprogress.com/english/question_answering.html) with the GPT2 double heads model neural network. The dataset (tab delimited) is...

22 November 2019 3,796 1 View

How to distinguish "elementary English" from "advanced English"?

Hello, When we take a look at English test prep books that are specially designed for ESL learners, we often see in their title that the book is for "learners at elementary level", "learners at...

15 November 2019 5,393 1 View

Can someone please guide me to a software that I can use to create time lapse models for the marine environment?

I am working on a concept related to the formation of coral reefs and I need to demonstrate the concept in the form of a visual model that changes over time. I am fairly new to this area of...

16 November 2018 9,276 4 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View

XRPD Quantification - Building a calibration curve of drug excipient?

I am aiming to utilise XRPD to quantify a drug excipient within a drug product and have been having a little trouble building the calibration curve to allow for this quantification up until this...

10 February 2021 6,145 3 View

Is this grounds for theophylline toxicity even though her plasma is within the therapeutic range? if it is, how is that possible?

A patient was given 300 mg Theophylline taken twice a day for the treatment of her bronchial asthma and has a positive clinical response. She has been compliant in taking her medication however,...

09 February 2021 3,489 3 View